MASTOFIN AZ®
Reg. SAGARPA: Q-0021-092

INTRAMMAMARY ANTIMICROBIAL
VETERINARY USE

INTRAMMAMARY SOLUTION. FOR THERAPY OF MASTITIS ACUTE, SUB-ACUTE
AND CHRONIC FOR COWS IN PRODUCTION

FORMULA:

INDICATIONS:
For therapy of acute, sub-acute and chronic mastitis caused by organisms sensitive to cloxacillin and spiramycin in cattle, goats and sheep.

DOSE:
1 syringe per quarter, after milking. Repeat dosing according to disease evolution.

These are average doses and will be administered and/or repeated according to case severity, under veterinary control and supervision.

VIA DE ADMINISTRACIÓN: Intrammamary.
It is recommended after milking, after udder cleaning and disinfection with an antiseptic, the total content of syringe must be administered en each nipple. After removing syringe, a rotary massage should be done and ascending to the udder with both hands, for a better antibiotic distribution in each quarter and at the end a sealing liquid must be put at each nipple.

WARNINGS:
Do not use milk for human consumption until 16 days hours after last dose.
Meat from treated animals must not be consumed until 33 days after last treatment.
- Shake before use.
- Keep in a dark and fresh place for storing.

PRESENTATION: Box with 20 syringes.

CONSULT VETERINARIAN
MEDICAL PRESCRIPTION IS NECESSARY FOR SALE

MASTOFIN-AZ® is a powerful antimocribial combinationfor therapy of clinical mastitis. In several studies, minimum inhibitory concentrations of cloxacillin for most of Streptococcus sp. and Staphylococcus sp. causing mastitis is 0.5 μg/ml. This is, at least, 10 times less than most of penicillins. This is because of the chemical group that protects the β-lactamase ring. Then resistance in most of Gram-positive coccus is virtually nil. Additionally, it has been shown that most of antimicrobials inhibit action of mammary macrophages. Cloxacillin in MASTOFIN-AZ®, DO NOT inhibit defense functions at mammary level, which is basic for healing and health of this tissue.

An excellent protection of post-partum mastitis has been achieved specially that caused by Staphylococcus sp. by the use of MASTOFIN-AZ® in the immediately previous period before labor.

Spiramycin in MASTOFIN-AZ® cooperates in destruction of Gram-positive bacteria causing mastitis. In most of mastitis cases, pH is elevated. This pH change is ideal for optimal function of spiramycin. In case there are Staphylococcus sp. resistant to
Cloxacillin, it is very difficult to find Staphylococcus sp. that resist double attack by spiramycin-cloxacillin.

It is known that mastitis affects production up to 50% of affected quarter after therapy. This is because of severe inflammatory process and substitution of glandular tissue by connective tissue. The balanced formula of MASTOFIN-AZ® includes an anti-inflammatory steroid that reduce glandular damage for excessive swelling, and papain, an enzyme that reduce collagen and fibrin deposit and reduce loss of production after a mastitis process.