CADEF FORTE 50%®
Reg. SAGARPA: Q-0021-053

RECONSTITUENT
VETERINARY USE

INJECTABLE SOLUTION PREVENTION AND TREATMENT OF CALCIUM METABOLIC DISORDERS

FORMULA:

INDICATIONS:

It is indicated for prevention and therapy of: Hypocalcemia (milk fever), pregnancy and lactation tetanies, ketonemia, eclampsy, rachitism, osteomalasya, bone structure repair, ketonuria, anemia, allergies, food poisoning, carbon tetrachloride intoxication, lead intoxication, fluoride intoxication, weakness in newborns (associated to Parfosal), calcium replacement, reconstituent during pregnancy and lactation. It is recommended for prevention of  fallen cow syndrome by administering immediately postpartum.

CADEF-FORTE 50%® by containing 50 g of Calcium borogluconate, cobres requirements for prevention and therapy of calcium deficiencies.
CADEF-FORTE 50%® is conditioned with phospforus as magnessium that works as metabolism stimulant impoving calcium metabolism.

DOSE:

Note: Dose is increased or reduced according to animal weight.

ROUTE OF ADMINISTRATION:  Intravenous, intramuscular

If administered by intravenous route, apply product slowly at body temperature.
If calcium deficiency is serious, it is recommended to apply half the dose by intravenous route and the other half by subcutaneous or intramuescular routes.

WARNINGS:
- Intravenous administration must be slow and at body temperature.
- Extract liquid aseptically to avoid contamination.
- Sep in a dark and fresh place for storing.

PRESENTATION: 100 ml vials

CONSULT VETERINARIAN

MEDICAL PRESCRIPTION IS NECESSARY FOR SALE

Calcium and Phosphorus:
Calcium and phosphorus have an important role in metabolic processes regulated by parathormone, calcitonin and vitamin D, specifically on bones, kidneys and intestine in order to balance their levels in the body.
If calcium and phosphorus levels are nor adequate, alterations may occur in acid-base balance, bone development, neuromuscular function, haemostasis and milk production, among other processes.

Mechanism of action:
Ionized calcium concentration in plasma is kept by several mechanisms, among them, intestinal absorption from gut, fast exchange with bone calcium and excretion by kidney route. Parathyroid hormone and vitamin D have main functions in calcium homeostasis. A reduction in calcium concentration increases secretion of parathyroid hormone while its elevations inhibits it. Calcium homeostasis is directed to avoid hypocalcaemia, which can produce tetany and risk of death, and that is why when factors as farrowing, lactation, etc. can lead to a hypocalcaemia situation in which supplementation becomes necessary immediately

Calcium borogluconate:
Is adequate for administration in large doses by intravenous route  (according to indications) intramuscular and subcutaneous, for prevention and therapy of conditions elevating calcium requirements. Fast administration should be avoided because of the risk of arrhythmia and hearth blocking

Magnessium hypophosphite:
Besides being and important phosphorus source, it is to a lesser degree of magnesium. Magnesium has important functions as metabolism of ATP regulator, in cell membrane functions, nerve conductivity and several hormone and enzymatic processes. Its administration is recommended by the intravenous route.Hipofosfito de magnesio:
Aparte de ser una importante fuente de fósforo, también lo es en menor grado de magnesio. El magnesio tiene importantes funciones como en la modulación del metabolismo del ATP, en las funciones de la membrana celular, en la conductividad nerviosa y diversos procesos hormonales y enzimáticos. Se recomienda también su aplicación lenta vía endovenosa.

Cafein:
It is an analeptic (stimulant of central nervous system) derived from methylxantine that increases alert state, reduces fatigue sense and increases muscular work capacity. It has a wide safe margin in all species. Inhibits phosphodysterease, and has a diuretic effect and is preferred for treatment of bronchial spasm and asthma.
Cafein stimulate adrenal cortex and medullar centers, increases mental alert and reduces response time for motor activity. One of its main effects is respiratory stimulation and bronchial dilation as well as an increase in cardiac frequency.